Advances in Biochemistry

Volume 6, Issue 5, October 2018

  • Buforin III Analogs Bind to DNA and Actin and Inhibit Bacterial Growth

    Nurit Beyth, Edna Blotnick-Rubin, Yael Houri-Haddad, Shaul Beyth, Andras Muhlrad

    Issue: Volume 6, Issue 5, October 2018
    Pages: 39-46
    Received: Oct. 25, 2018
    Accepted: Nov. 09, 2018
    Published: Dec. 14, 2018
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    Abstract: Buforin is a cationic antimicrobial peptide (AMP) from the stomach of toads. Buforin II is a derivative of this naturally occurring peptide. Buforin IIB is a synthetic analog of buforin II containing a model α-helical sequence (3xRLLR) at the C-terminus. To further increase the antimicrobial activity and decrease toxicity to eukaryotic cells, new d... Show More