An aphrodisiac is any substance (i.e. food or drug) that arouses the sexual instinct, increases sexual pleasure and performance. Aphrodisiacs can be classified as natural remedies such as Ambrien, Ginseng and Yohimbine and synthetic aphrodisiacs like ecstasy, synthetic testosterone, phenethylamines and methamphetamine. Tsumi concoction (TC) is a herbal concoction made from Ficus sycomorus, Ginger, Clove, Honey and Brown sugar (Jaggery). Mi Jian Fen (MJF) is an aphrodisiac imported from Spain. This study investigated the effect of TC and MJF aphrodisiacs on biochemical parameters in adult female Wistar albino rats. Adult rats weighing between 160-220g were grouped into six (6) groups with three (3) animals in every group. Group 1 serve as the control, group 2 were administered with 0.2mg/kg of clomid as the standard drug, while group 3 and 4 received high and low (0.4mg/kg and 0.2mg/kg) doses of MJF while group 5 and 6 received high and low (0.4mg/kg and 0.2mg/kg) doses of TC, respectively. The results revealed significant increase (p<0.05) in the ALP and AST levels among all the test groups and a slight increase in ALT compared to the control group. It was followed by significant increase (p<0.05) in serum level of oestrogen and FSH. There was significant increase (p<0.05) in urea and a slight elevations in creatinine levels in all the treated groups. However, moderate changes in the Haematological parameters were also observed. It was concluded that MJF and TC are potent aphrodisiacs with some level of toxicity. Therefore, utilization of MJF and TC which caused kidney and liver damages in albino rats, could have deleterious side effects among human users.
| Published in | Advances in Biochemistry (Volume 11, Issue 1) |
| DOI | 10.11648/j.ab.20231101.12 |
| Page(s) | 8-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ficus Sycomorus, TC, MJF, Aphrodisiacs, Biochemical Parameters, Clomiphene Citrate, Wistar Albino Rats
| [1] | Da Cruz, A. C., Guerra, N. G., de Souza, K. E. B. P., Eleutѐrio, I. D., da Silva, L. C., Otoni, E. G., Alves, M. R. A. (2017). The action of herbal medicine on the libido: aspect of nutritional intervention in increasing sexual desire. Nutrire 42, 29. http://doi.org/10.1186/s41110-017-0051-1. |
| [2] | Abdo C. H. N., Fleury H. J. (2006). Aspectos diagnósticos e terapêuticos das disfunções sexuais femininas. Revista de Psiquiatria Clinica. 33: 3–5. |
| [3] | Carteiro D. M. H., Sousa L. M. R., Caldeira S. M. A. (2016). Clinical indicators of sexual dysfunction in pregnant women: integrative literature review. Revista Brasileira de Enfermagem. 69: 1–9. |
| [4] | WHO, (2005). Resolution – promotion and development of training and research in traditional medicine, WHO Document No. WHA, 30-49. |
| [5] | WHO Media Centre (2011). Traditional Medicine. Fact sheet N°134 2008 (http://www.who.int/mediacentre/factsheets/fs134/en/) |
| [6] | WHO, (2008). Resolution – Drug policies and management: Journal of medicinal plants. WHO Document NO. WHA, 31-33. |
| [7] | Oreagba A. I., Oshikoya A. K., Amachre M. (2011). Herbal medicine use among urban residents in Lagos, Nigeria. BMCComplementary and Alternative Medicine, www.biomedcentral.com/1472-6882/11/117 |
| [8] | Umar Lawal Bello, Jibrin Isah (2015). Use of Herbal Medicines and Aphrodisiac Substances amongWomen in Kano State, Nigeria. IOSR Journal of Nursing and Health Science (IOSR-JNHS). e-ISSN: 2320–1959. p-ISSN: 2320–1940 Volume 4, Issue 4 Ver. III (Jul. - Aug. 2015). |
| [9] | Yakubu M. T., Akanji M. A., Oladiji A. T. (2005). Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian J Androl. 7: 399–404. |
| [10] | Ang H. H., Chan K. L., Gan E. K., Yuen K. H. (1997). Enhancement of sexual motivation in sexually naive male mice by Eurycoma longifolia, jack. Int J Pharmacogn. 35: 144–6. [Google Scholar] "Aphrodisiac". Online Etymology Dictionary by Douglas R. Harper (2003). |
| [11] | Personal contact (2022). |
| [12] | Odebode A. A., Awoye I. B. (2022). Attitude of literate married men towards the use of aphrodisiac herbs in Ilorin, Kwara state, Nigeria. Afri Health Sci. 22 (2): 428-435. https://dx.doi.org/10.4314/ahs.v22i2.49 |
| [13] | Haj. Fa’iha. Personal contact (2022). |
| [14] | Alh. Musa. Personal contact (2022). |
| [15] | Christensen, A., G. E, B., R., C., H. H, O., Perfito, N., Wu, T., Micevych, P. (2012). Hormonal Regulation of Female Reproduction. National Institute of Health, 44 (8), 587–591. https://doi.org/10.1055/s-0032-1306301.Hormonal |
| [16] | Yakubu M. T., Olutoye A. F. (2016). Aphrodisiac activity of aqueous extract of Anthonotha macrophylla P. Beauv. leaves in female Wistar rats. J Integr Med. 14 (5): 400–408. |
| [17] | Joseph Kasyoki Peter (2021). Effects of kenyan grewia tenax (mukawa wa guba) root extract on female wistar albino rats’ estrus cycle and reproductive hormones. |
| [18] | Tijjani U., Mabrouk M. I., Yarube I. U., Muhammad M. (2018). Aphrodisiac Effect of Aqueous Stem Bark Extract of Ficus Sycomorus on Female Wistar Rats. Nigerian Journal of Basic and Applied Science (June, 2018), 26 (1): 70-79 DOI: http://dx.doi.org/10.4314/njbas.v26i1.8. |
| [19] | Etim Oboso E., Ndem Jessie I., Basse Utibe Evans (2016). Effect of ethanol leaves extract of Justicia schimperi on liver enzymes, serum proteins and bilirubin. Int J Res Med Sci. 4 (7): 2593-2597 DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20161915. www.msjonline.org |
| [20] | Wael M. Al-Amoudi (2012). Biochemical and Histological Effects of Clomiphene Citrate on Liver of Female Albino Rat. Journal of American Science. 8 (5): 646-651]. (ISSN: 1545-1003). http://www.americanscience.org. |
| [21] | Hatoff D. E and Hardison W. J (1980). Hepatic bile acid content control alkaline phosphatase during cholestasis). Gastroenterology 78: 1307. |
| [22] | Joseph E Eyo, Lilian O Nwachukwu, Ikechukwu E Onah, Chinedu I Atama, Felicia N Ekeh, Ngozi E Ezenwaji, Njoku Ivoke (2013). Effects of the Aqueous Root Extract of Vernonia amygdalina on the Haematological Profile of Rattus norvegicus. Advances in Life Science and Technology. www.iiste.org ISSN 2224-7181. Vol. 11. |
| [23] | Chike C. P. R., Njoku B., Green K., Akpojotor P. I., Onyebuenyi M. O., Numbara Deebii (2018). Effect of Ethanolic Leaf Extract of Vernonia amygdalina (Bitter Leaf) Extract on some of the Haematological Parameters in Wistar Rats. Journal of Complementary and Alternative Medical Research. 5 (1): 1-7.35690 ISSN: 2456-6276. |
| [24] | Agaia B. M., Onyeyili P. A., Muhammad B. Y., Ladan M. J. (2007). Some toxic effect of aqeous leaf extract of Anogeissus leiocarpus in Rats. Journal of Pharmacology and Toxicology. 2 (4): 396-401. |
APA Style
Farida Suleiman Abubakar, Fatima Aminu, Moses Zira Zaruwa, Bawa Yusuf Muhammad, Titilayo Oluwayemisi Bamidele, et al. (2023). Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats. Advances in Biochemistry, 11(1), 8-14. https://doi.org/10.11648/j.ab.20231101.12
ACS Style
Farida Suleiman Abubakar; Fatima Aminu; Moses Zira Zaruwa; Bawa Yusuf Muhammad; Titilayo Oluwayemisi Bamidele, et al. Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats. Adv. Biochem. 2023, 11(1), 8-14. doi: 10.11648/j.ab.20231101.12
AMA Style
Farida Suleiman Abubakar, Fatima Aminu, Moses Zira Zaruwa, Bawa Yusuf Muhammad, Titilayo Oluwayemisi Bamidele, et al. Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats. Adv Biochem. 2023;11(1):8-14. doi: 10.11648/j.ab.20231101.12
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ab.20231101.12,
author = {Farida Suleiman Abubakar and Fatima Aminu and Moses Zira Zaruwa and Bawa Yusuf Muhammad and Titilayo Oluwayemisi Bamidele and Chibuzo Carole Nweze and Saratu Steven Audu},
title = {Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats},
journal = {Advances in Biochemistry},
volume = {11},
number = {1},
pages = {8-14},
doi = {10.11648/j.ab.20231101.12},
url = {https://doi.org/10.11648/j.ab.20231101.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20231101.12},
abstract = {An aphrodisiac is any substance (i.e. food or drug) that arouses the sexual instinct, increases sexual pleasure and performance. Aphrodisiacs can be classified as natural remedies such as Ambrien, Ginseng and Yohimbine and synthetic aphrodisiacs like ecstasy, synthetic testosterone, phenethylamines and methamphetamine. Tsumi concoction (TC) is a herbal concoction made from Ficus sycomorus, Ginger, Clove, Honey and Brown sugar (Jaggery). Mi Jian Fen (MJF) is an aphrodisiac imported from Spain. This study investigated the effect of TC and MJF aphrodisiacs on biochemical parameters in adult female Wistar albino rats. Adult rats weighing between 160-220g were grouped into six (6) groups with three (3) animals in every group. Group 1 serve as the control, group 2 were administered with 0.2mg/kg of clomid as the standard drug, while group 3 and 4 received high and low (0.4mg/kg and 0.2mg/kg) doses of MJF while group 5 and 6 received high and low (0.4mg/kg and 0.2mg/kg) doses of TC, respectively. The results revealed significant increase (p<0.05) in the ALP and AST levels among all the test groups and a slight increase in ALT compared to the control group. It was followed by significant increase (p<0.05) in serum level of oestrogen and FSH. There was significant increase (p<0.05) in urea and a slight elevations in creatinine levels in all the treated groups. However, moderate changes in the Haematological parameters were also observed. It was concluded that MJF and TC are potent aphrodisiacs with some level of toxicity. Therefore, utilization of MJF and TC which caused kidney and liver damages in albino rats, could have deleterious side effects among human users.},
year = {2023}
}
TY - JOUR T1 - Effect of Local (Tsumi) and Foreign (Mi Jian Fen) Aphrodisiac on Biochemical Parameters in Wistar Albino Rats AU - Farida Suleiman Abubakar AU - Fatima Aminu AU - Moses Zira Zaruwa AU - Bawa Yusuf Muhammad AU - Titilayo Oluwayemisi Bamidele AU - Chibuzo Carole Nweze AU - Saratu Steven Audu Y1 - 2023/05/18 PY - 2023 N1 - https://doi.org/10.11648/j.ab.20231101.12 DO - 10.11648/j.ab.20231101.12 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 8 EP - 14 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20231101.12 AB - An aphrodisiac is any substance (i.e. food or drug) that arouses the sexual instinct, increases sexual pleasure and performance. Aphrodisiacs can be classified as natural remedies such as Ambrien, Ginseng and Yohimbine and synthetic aphrodisiacs like ecstasy, synthetic testosterone, phenethylamines and methamphetamine. Tsumi concoction (TC) is a herbal concoction made from Ficus sycomorus, Ginger, Clove, Honey and Brown sugar (Jaggery). Mi Jian Fen (MJF) is an aphrodisiac imported from Spain. This study investigated the effect of TC and MJF aphrodisiacs on biochemical parameters in adult female Wistar albino rats. Adult rats weighing between 160-220g were grouped into six (6) groups with three (3) animals in every group. Group 1 serve as the control, group 2 were administered with 0.2mg/kg of clomid as the standard drug, while group 3 and 4 received high and low (0.4mg/kg and 0.2mg/kg) doses of MJF while group 5 and 6 received high and low (0.4mg/kg and 0.2mg/kg) doses of TC, respectively. The results revealed significant increase (p<0.05) in the ALP and AST levels among all the test groups and a slight increase in ALT compared to the control group. It was followed by significant increase (p<0.05) in serum level of oestrogen and FSH. There was significant increase (p<0.05) in urea and a slight elevations in creatinine levels in all the treated groups. However, moderate changes in the Haematological parameters were also observed. It was concluded that MJF and TC are potent aphrodisiacs with some level of toxicity. Therefore, utilization of MJF and TC which caused kidney and liver damages in albino rats, could have deleterious side effects among human users. VL - 11 IS - 1 ER -
Email: